BPC-157
CAS #: 137525-51-0
Research Use Only
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BPC-157 Overview
BPC-157 is a synthetic pentadecapeptide composed of 15 amino acids. It was originally derived from a naturally occurring protein fragment identified in gastric tissue. Since its discovery in the early 1990s, BPC-157 has been studied extensively in controlled experimental settings for its potential influence on molecular signaling, structural remodeling, and angiogenic processes.
History
The peptide was first synthesized by researchers investigating cytoprotective proteins found in gastric juice. Early experiments focused on its ability to support structural integrity in gastric models. Over time, studies broadened into structural, vascular, and epithelial systems, where BPC-157 consistently demonstrated properties of interest in the context of molecular remodeling and biological resilience.
BPC-157 Structure
- CAS #:
- 137525-51-0
- Molecular Formula:
- C62H98N16O22
- Molecular Weight:
- 1419.556 g/mol
- PubChem ID:
- 108101
Research Findings
BPC-157 has been studied in structural, vascular, epithelial, and systemic models, with reports of activity in collagen regulation, extracellular matrix remodeling, angiogenesis, and molecular migration. Research also highlights signaling roles in preclinical systems, supporting molecular integrity and pathway dynamics.
Key Areas of Research:
- Structural: Collagen, matrix, tendon
- Vascular: Angiogenesis, nitric oxide, signaling
- Epithelial: Migration, vessel formation, matrix
- Systemic: Signaling, viability, pathway dynamics
References
- Sikiric P. et al. (1993). A new gastric juice peptide, including BPC-157, characterized and synthesized.
- Pavlovic I. et al. (2003). The promoting effect of pentadecapeptide BPC-157 on tendon healing involves tendon outgrowth, cell survival and cell migration.
- Staresinic M. et al. (2003). Effects of BPC-157 on ligament and tendon repair in experimental models.
- Chang CH. et al. (2009). Protective effects of BPC-157 in experimental colitis models.
- Hsieh MJ. et al. (2015). Therapeutic potential of pro-angiogenic BPC-157 in wound healing and burn models.
- Seiwerth S. et al. (2018). Mechanisms of angiogenic activity and NO-system modulation by BPC-157
- Kang EA. et al. (2025). Protective effects of BPC-157 on liver, kidney, and lung in ischemia-reperfusion injury models.
